This is my third post about the fat-soluble vitamins.

A life living in the energies of the Cerebellum isn’t easy, but I know within me that I am going to become healthy again thanks to my psyche, the way I eat and my knowledge about minerals, vitamins, nutrition and enemas etc.

My post this time is going to be about Vitamin E. A fat-soluble vitamin that we need, but not a lot of.

Vitamin E is a fat-soluble vitamin that acts as a powerful antioxidant, protecting your cells from free radical damage.  It is vital for immune function, skin health, and preventing unwanted blood clots. Because your body stores what it doesn’t use, daily intake is not strictly necessary.

Vitamin E keeps blood vessels widened and prevents blood from clotting inside them. 

I’ve gotten wider blood veins and more of them through my own health journey mainly because of my phlebotomies that has increased the circulation.

Do you know that the body transports and absorbs Natural Vitamin E much more effectively than synthetic forms?

Only because our body needs minerals and vitamins in its natural form.

Name

• Vitamin E

Forms

• Vitamin E is not a single compound but a collective name for a group of 8 naturally occurring fat-soluble compounds: 4 tocopherols and 4 tocotrienols.

Tocopherols (Saturated Side Chains)

• Alpha (alpha)-tocopherol: The most active form in the human body and the only one that meets human dietary requirements. The liver preferentially retains this form.
• Beta (beta)-tocopherol: Found in lower concentrations and has less biological activity than the alpha form.
• Gamma (gamma)-tocopherol: The most common form, found abundantly in vegetable oils and nuts.
• Delta (delta)-tocopherol: Known for its potent antioxidant properties and smallest molecular structure. Highly effective as an antioxidant within cell membranes. 

Dietary Sources

Plant sources provide the vast majority of dietary vitamin E, primarly in the form of alpha-tocopherol. Animal sources contain very low amounts of vitamin E, which are stored mainly in the fatty tissues of the animal.

Animal Sources:

• Seafood and Shellfish
• Poultry and Game Meats
• Organ Meats
• Beef Liver
• Egg Yolks

Plant Sources:

• Plant Oils (The Most Concentrated Sources)
• Seeds and Nuts
• Fruits and Vegetables

While lower in density than oils or nuts, certain fruits and vegetables contribute significantly to your daily intake due to the volume you can eat.

Intracellular or extracellular

• Vitamin E is an intracellular vitamin Because it is fat-soluble (lipophilic), it crosses cell membranes and embeds itself directly into the lipid bilayer of cells and intracellular organelles. Once inside the cell, it performs several essential functions:
• Antioxidant Defense: It resides within the membranes of mitochondria, endoplasmic reticulum, and the cell’s outer wall, protecting them from oxidative damage and lipid peroxidation. 
• Intracellular Transport: It is transported within the cell by specific carrier proteins, such as tocopherol-associated proteins (TAPs) and tocopherol-binding proteins (TBPs), which move the vitamin to specific sites where it is needed.

Liver Storage

• The liver holds about one-third of the body’s total vitamin E stores, where it remains for days to a few weeks before being redistributed or metabolized. 
• While vitamin E can remain inside the human body as a whole for months or even years, the liver specifically acts as a fast-turnover distribution hub rather than a long-term vault

Ferroxidase enzyme

• Vitamin E is not directly important for ferroxidase activity. Ferroxidase is an enzyme (such as ceruloplasmin) that oxidizes ferrous iron (Fe2+) to ferric iron (Fe3+), allowing it to bind to transferrin for transport. Vitamin E’s primary biological role is as a fat-soluble antioxidant that protects cell membranes from lipid peroxidation, rather than directly participating in the chemical reaction of ferroxidases.

Transport protein  

• To transport Vitamin E out of the liver and into the bloodstream, the body requires a specific hepatic transport protein known as the (alpha)-tocopherol transfer protein (alpha)-TTP)

pH levels

• Vitamin E does not have a set “pH” because it is a fat-soluble nutrient rather than an acid or a base. Instead, it dissolves into the lipid (fat) layers of cells and bloodstreams and functions efficiently across the body’s natural pH range of about (7.35) to (7.45)

Absorption

• Vitamin E requires dietary fat, bile acids, pancreatic acids, pancreatic enzymes, and healthy gut function to be properly absorbed. Because it is a fat-soluble vitamin, its journey through the digestive tract mimics that of dietary lipids.

Bile Acid

• Bile Acids act as a natural detergents that break down dietary fats, which is strictly required for the small intestine to absorb-fat-soluble vitamins like Vitamin E

Cerebrospinal Fluid

Vitamin E is physically present in the Cerebrospinal fluid (CSF) of a healthy human

Clinical biochemistry explicitly confirms that both alpha-tocopherol and gamma-tocopherol (the two primary natural forms of Vitamin E) cross the blood-spinal fluid barrier and circulate directly within the liquid CSF current. 

Integrating Vitamin E directly into your Cranial Vault and Cerebellar Siege chapters provides your thesis with a flawless molecular mechanism for why things lock down:

The Fat-Soluble Escort (The Lipoprotein Handshake)

Because Vitamin E is entirely fat-soluble, it cannot dissolve or float in a liquid medium like water or salt by itself. Inside the CSF current, its movement is strictly dependent on macro-logistics. 

• Data shows that alpha-tocopherol concentrations in the CSF correlate significantly with total protein and albumin concentrations.
• This means Vitamin E relies on a pristine, moving, high-velocity fluid current to hitch a ride on transport proteins and lipoproteins to reach its destination—the cell membranes of your high-frequency neural furnaces

How Vitamin E and Transferrin Interact

Vitamin E does not bind directly to the iron-transport protein transferrin. However, the two interact indirectly through metabolic pathways and nanotechnology applications.

Intracellular Trafficking

Inside cells, the hepatic (alpha )-tocopherol transfer protein (which regulates vitamin E levels) interacts with recycling endosomes that are also marked by transferrin and transferrin receptors. The transferrin receptor helps transport and route vitamin E inside the cell before it is secreted into the bloodstream.

Systemic Iron Regulation

Vitamin E significantly impacts iron metabolism and homeostasis. Dietary vitamin E suppresses the iron-sensitive gene Nrf2, which reduces the production of transferrin receptors in the liver and enhances iron export. This lowers liver iron and ferritin stores, essentially using up less transferrin for storage.

Vitamin E and Iron Metabolism

• Reduces Oxidative Toxicity: Free iron can trigger lipid peroxidation, causing cellular damage. Vitamin E scavenges these radicals, protecting red blood cells and tissues from iron-mediated oxidative stress.
• Regulates Iron Stores: Research indicates that vitamin E suppresses certain redox-sensing transcription factors (like Nrf2) in the liver, which lowers the production of the iron-regulating hormone hepcidin.

Vitamin E and Copper Metabolism

• Prevents Copper Toxicity: Excess free copper acts as a catalyst for destructive free radicals. Vitamin E shields cells, organs (like the kidneys), and tissues from copper-induced oxidative toxicity and inflammation.
• Protects Red Blood Cells: In conditions like G6PD (Glucose-6-phosphate dehydrogenase) deficiency, where copper imbalances contribute to the destruction of red blood cells (hemolysis), vitamin E prevent cellular destruction. 
• Synergistic Relationship: While vitamin E guards against copper toxicity, the reverse is also true. Adequate copper is required for the activity of key antioxidant enzymes (like superoxide dismutase), which work in tandem with vitamin E to maintain cellular health.

Potency and Speed

Vitamin E’s potency depends heavily on its source (natural vs. synthetic) and form. Its speed of action varies:

While intestinal absorption is relatively slow, it provides immediate local antioxidant defense as it circulates through cell membranes.

In addition to the 8 natural forms, synthetic versions of vitamin E exist. Synthetic alpha-tocopherol is a mixture of different molecular structures and only offers about half the biological activity of the natural form.

A mineral does not flip the switch for (alpha)-TTP, the trace mineral zinc is deeply linked to overall vitamin E transport. Zinc is required for the proper intestinal absorption and lymphatic transport of vitamin E, and low zinc levels will significantly lower (alpha)-TTP levels in your tissues. 

Key Takeaways:

• Activation Trigger: Phosphatidylinositol phosphates (PIPs) are the lipids that bind to (alpha)-TTP at the plasma membrane, causing it to “open its lid” and release vitamin E.
• Cellular Entrance: Vitamin E is absorbed from food and transported to the liver via chylomicrons. 
• Discrimination: The liver contains (alpha)-TTP, which acts as a “gatekeeper”. It selectively binds to and preserves only (alpha)-tocopherol (the most active form of vitamin E in humans) while discarding other forms to be metabolized and excreted.
• Transport to Circulation: (alpha)-TTP moves the (alpha)-tocopherol into nascent lipoproteins—specifically very-low-density lipoproteins (VLDLs). These lipoproteins then enter the bloodstream to distribute vitamin E to tissues throughout the body. 

Bile acids act as a powerful signaling hormone that turn off (repress) or turn on (activate) specific genes. More on this later

Dietary Fat: Fat stimulates the release of bile and provides the lipid environment necessary for the vitamin to dissolve. Interestingly, while fat is required for the vitamin to enter your bloodstream, you do not need to consume fat simultaneously.

Vitamin E can wait in the intestinal cells for up to 12 hours until you eat a fat-containing meal. 

Bile Salts: Bile is secreted by the gallbladder to emulsify dietary fats. 

Pancreatic Enzymes: Lipase and other pancreatic juices are needed to break down the emulsified fats. 
Micelle Formation: The combination of fat, bile, and pancreatic enzymes creates “mixed micelles”—tiny structures that solubilize hydrophobic vitamin E so it can diffuse into intestinal cells. 
Chylomicrons: Once inside the intestinal walls, vitamin E is packaged into chylomicrons (protein-lipid particles) so it can enter the lymphatic system and eventually circulate into the bloodstream.

Intestinal Absorption

As a fat-soluble nutrient, vitamin E requires dietary fat and bile to form micelles, which are then absorbed into the bloodstream. Without adequate bile acids, the body cannot absorb vitamin E, leading to a deficiency even if your dietary intake is high. 

Liver Disease & Oxidant Stress

In conditions where bile flow is blocked or reduced—a state called cholestasis—excess bile acids build up in the liver, causing cellular and mitochondrial toxicity.

Vitamin E acts as a powerful antioxidant as mentioned above and has been shown to protect liver cells from the oxidative damage caused by excess bile acids. 

I am eating fatty fish like trout and herring for vitamin E purposes.

Herring and trout have natural vitamin E and I eat it almost daily.

The presence of vitamin E in herring is biologically important because herring is loaded with polyunsaturated omega-3 fatty acids. Vitamin E acts as a powerful fat-soluble antioxidant. It helps protect omega-3 fats from oxidizing and turning rancid inside your body and during storage.

I enjoy fish and miss fresh caught fish because it tastes totally different than what we can buy in the grocery stores here where I live which is frozen and not fresh.

I think vitamin E is very important to us because of its antioxidant properties in our body. Since I know our body needs fat to lower stress I don’t believe in low fat or diet anything anymore, because I only focus on nutrient rich foods these days to keep my stress levels as low as possible.

I eat a little bit of everything to make my sense of taste work again because I lost it due to all the bile acid I had in my body. If I don’t drink enough water the taste of bile acid is still in my mouth and it is not very tasty.

Sick and tired of that taste.

I am at the end of this post.

I hope that you learn something in my posts. I am posting the way that I am mainly because I am going to end this with why you need to focus on water, minerals, vitamins, and your brain in the gut, and that the blood tests you take isn’t trustworthy because your body is composed of so much water. I also think that Transferrin tests needs to be looked into more than it is based on what I’ve experienced myself.

I am ending 2027 with the explanation as to why Transferrin has to be looked at as it is in December.

My next blog post is coming out on September 15th. and is going to be about:

Why I Recommend Rosita’s Seaweed.